Haupt-Darsteller
- Ellen Pompeo (Meredith Grey)
- Staffel 1 - 4
- Patrick Dempsey (Dr. Derek Shepherd)
- Staffel 1 - 4
- James Pickens Jr. (Dr. Richard Webber)
- Staffel 1 - 4
- T.R. Knight (George O'Malley)
- Staffel 1 - 4
- Sandra Oh (Cristina Yang)
- Staffel 1 - 4
- Katherine Heigl (Isobel "Izzie" Stevens)
- Staffel 1 - 4
- Chandra Wilson (Dr. Miranda Bailey)
- Staffel 1 - 4
- Isaiah Washington (Dr. Preston Burke)
- Staffel 1 - 3
- Justin Chambers (Alex Karev)
- Staffel 1 - 4
- Kate Walsh (Dr. Addison Shepherd)
- Staffel 2 - 3
- Eric Dane (Mark Sloan)
- Staffel 3 - 4
- Sara Ramirez (Callie Torres)
- Staffel 2 - 4
- Chyler Leigh (Lexie Grey)
- Staffel 4
